Testicular cancer

Testicular cancer

The testes are a pair of male sex organs which hang within the scrotum beneath the penis. Testicular cancer refers to malignancy in one or both the testicles. It usually occurs in young or middle aged men and is rare after the age of 50. The most common form of testicular cancer arises from the germ cells, known as germ cell testicular cancer. Other forms of testicular cancers are Leydig cell tumors, Sertoli cell tumors and lymphomas.

Causative & risk factors

The exact cause of testicular cancer is not known but several risk factors have been identified. White men have a much higher risk of developing testicular cancer, so do men with a family history of this disease. History of undescended testicles is also associated with a higher risk of developing testicular cancer. This condition is also more common in men who are infertile and those who smoke.


Clinical presentation

The commonest presentation of cancer in the testes is presence of a painless lump. Occasionally a sense of heaviness or a dull ache may be felt. Testicular cancer can produce a hydrocele.


Testicular cancer is staged as follows:

Stage 1 – the cancer is within the testicles

Stage 2 – the cancer has spread into the regional lymph nodes

Stage 3 – the cancer has spread into the lymph nodes at distant sites such as the chest

Stage 4 – the cancer has metastasized to other organs



If your doctor suspects testicular cancer on the basis of physical examination, several tests will be carried out to confirm its presence.

Blood samples are taken to test for markers of testicular cancer, which include Alpha feta protein (AFP), human chorionic gonadotrophin (HCG) and lactate dehydrogenate (LDH).

An ultrasound scan of the scrotum will be performed. Sometimes a CT or MRI scan may be needed. Testicular biopsy is a confirmatory test to detect testicular cancer.



Compared to other forms of cancer, testicular cancer has a very good prognosis. Orchidectomy i.e. surgery to remove 1 or both the testicles is the treatment of choice. The regional lymph nodes may or may not be removed depending upon the spread of cancer. Surgery is followed by radiation therapy, chemotherapy or both.


Recent updates

Recent research has found several genetic variations that are present in men with testicular cancer. These will help identify men who are at a high risk of developing cancer of the testes. Role of stem cell transplant is also being studies for men suffering from testicular cancer.

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